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Erica L Mayer, Amylou C Dueck, Miguel Martin, Gabor Rubovszky, Harold J Burstein, Meritxell Bellet-Ezquerra, Kathy D Miller, Nicholas Zdenkowski, Eric P Winer, Georg Pfeiler, Matthew Goetz, Manuel Ruiz-Borrego, Daniel Anderson Zbigniew Nowecki, Sibylle Loibl, Stacy Moulder, Alistair Ring, Florian Fitzal, Tiffany Traina, Arlene Chan, Hope S Rugo, Julie Lemieux, Fernando Henao, Alan Lyss, Silvia Antolin Novoa, Antonio C Wolff, Marcus Vetter, Daniel Egle, Patrick G Morris, Eleftherios P Mamounas, Miguel J Gil-Gil, Aleix Prat, Hannes Fohler, Otto Metzger Filho, Magdalena Schwarz, Carter Du Frane, Debora Fumagalli, Kathy Puyana Theall, Dongrui Ray, Cynthia Huang, Maria Koehler, Christian Fesl, Angela De Michele, Michael Gnant - The Lancet Oncology. Volume 22, Issue 2, February 2021

Evento em formato virtual contará com palestrantes nacionais e internacionais em sua programação para discutir os principais avanços no diagnóstico e tratamento do câncer de mama. Entre os dias 9 e 11 de março de 2021, se realizará a Conferência Brasileira de Câncer de Mama 2021, e o evento oficial licenciado Best of SABCS Brazil. Este evento é organizado pelo Latin American Cooperative Oncology Group (LACOG) e Grupo Brasileiro de Estudos em Câncer de Mama (GBECAM), instituições brasileiras dedicadas à educação e pesquisa em câncer de mama. O evento deste ano será em formato virtual e reunirá especialistas nacionais e internacionais para debater os principais avanços no diagnóstico e tratamento do câncer de mama. O primeiro dia do evento será dedicado ao Best of SABCS Brazil, no qual os participantes poderão acompanhar o que foi destaque no San Antonio Breast Cancer Symposium – realizado em dezembro de 2020, nos Estados Unidos. O SABCS é um dos mais relevantes congressos mundiais que debate pesquisa básica, translacional e clínica em câncer de mama. Os principais temas abordados no encontro serão agora apresentados e discutidos com exclusividade no Brasil. Nos outros dias do evento teremos módulos dedicados ao tratamento de doença inicial e metastática apresentando

The Genitourinary Cancers Symposium, an event organized by the ASCO focused on presenting and debating the latest research, diagnoses and treatment for genitourinary cancer, took place between February 11 and 13 in an online format. LACOG participated by presenting two studies: Bladder Cancer Registry (LACOG 1518) and the APA in Prostate Cancer (LACOG 0415). The first study, presented by Dr. Vinícius Carrera Souza, an oncologists at Instituto D’Or – Bahia, as well as an investigator and executive director for LACOG Genitourinary Group, is centered around creating a multicentric Latin American database to analyze epidemiological, clinical and pathological data; treatment; results and biological information on patients diagnosed with recurrent/metastatic transitional cell carcinoma. The second study, presented by Dr. Andrey Soares, a clinical oncologist at Hospital Israelita Albert Einstein and Centro Paulista de Oncologia and scientific director of LACOG Genitourinary Group, is being conducted with Brazilian patients and assessed several therapeutic options that present fewer adverse events and consequently gains in life quality for individuals under treatment for prostate cancer. For more information and to enroll, visit: https://meetings.asco.org/gu/attend

This report highlights immune checkpoint inhibition with respect to chemotherapy-free regimens and new PD-1 inhibitors. Moreover, different types of therapy for early-stage lung cancer and determinants of treatment success in small-cell lung cancer are covered. Furthermore, innovative and established approaches for patients with uncommon mutations as well as EGFR-targeted options, possibly changing the treatment landscape, are addressed. Last but not least, this special issue includes expert interviews regarding the interactions between radiotherapy and the immune system and the implementation of immunotherapy-based standards for malignant mesothelioma. Additionally, on the memo website you will find expert video interviews with Paul Baas, Tony Mok, Maarten Lambrecht and Byoung Chul Cho on different conference highlights. The memo inOncology Special Issue report is produced by Springer, as a supplement of memo (the Magazine of European Medical Oncology) and sponsored by Boehringer Ingelheim and BeiGene with an unrestricted educational grant. For more information on the memo inOncology Special Issue series, and for free access to all previous editions, visit the memo-inOncology website. Download the ASCO 2020 Lung Cancer report

The Gynecologic Oncology Group (GOG) Foundation is an organization based in Columbia, in the United States, which works to promote clinical research in prevention and treatment of gynecologic cancers, such as ovarian, cervical , endometrial, vulvar, and vaginal cancers. The foundation has a network of over 400 members and has already given support on the conduction of 350 clinical trials, reaching over 115,000 patients.  Institutions and investigators that belong to the GOG Foundation network are extremely important for the development of treatments and surgical procedures, for the quality of life analyses and prevention knowledge. The institution has support from industry and the National Cancer Institute (NCI) to conduct trials and generate results that are shared with participating members, health professionals, patients, and their families. The GOG Foundation is focused on the advances in Oncology to benefit cancer patients.  LACOG has been working in partnership with the GOG Foundation, joining forces to support clinical studies. The aim of this partnership is to extend international cooperation to provide LACOG investigators the opportunity to participate in studies conducted worldwide.  Likewise, this partnership allows LACOG to expand its portfolio of clinical trials, which extends the opportunity for Latin-American patients to participate in clinical research with the most

Currently, the LACOG Gastrointestinal Cancer Group has two ongoing studies. The objective of these studies is to create databases of prognostic and predictive factors of patients with neuroendocrine tumors (LACOG 0119) and of patients with anal cancer (LACOG / GTG 1318 - CCA). Both studies are being conducted in partnership with the Gastrointestinal Tumors (GTG) Brazilian group.  According to Dr. Rachel Riechelmann, head of Clinical Oncology at the A.C.Camargo Cancer Center, president of the LACOG Gastrointestinal Cancer Group and principal investigator of LACOG 0119 and LACOG / GTG 1318 - CCA studies , these studies will help us to create an epidemiological database of two rare diseases. “Currently, there is no Brazilian or Latin American epidemiological data of neuroendocrine tumors and anal cancer. We have no information on what the most common histologic tumor subtype is, its prognosis, overall and progression-free survival rates in our region. Studies like these provide data regarding the characteristics of patient populations which help to define research strategies that are focused on these specific subgroups.”  Studies as the ones mentioned above would not be practicable without a partnership with LACOG which, according to Dr. Riechelmann, is the only collaborative research group in Latin America. “In fact, it

The incidence of cancer and its mortality rates have been increasing worldwide, especially in developing countries due to their growing and aging population. “Bladder cancer is the tenth most common cause of cancer across the world, with 549 thousand new cases and 200 thousand deaths estimated each year”, explains Dr. Vinícius Carrera Souza, an oncologist from the Instituto D'Or - Bahia and a researcher at LACOG.  According to Dr. Souza, little is known about the epidemiology, clinical-pathological characteristics, standard treatments and outcomes of advanced urothelial carcinoma of the renal pelvis, ureter, bladder or urethra in Latin America. “The latest estimates indicated that the incidence of bladder cancer is 7 per 100,000 in men and 2.3 per 100,000 in women. However, these data are probably underestimated due to scarcity of cancer records. Fortunately, there has been an increased interest in clinical and pathological information collection regarding metastatic urothelial cancer in Latin America.” Considering that, Dr. Souza began the Bladder Cancer Registry study (LACOG 1518). The study aims to create a Latin American multicenter database to analyze epidemiological, clinical and pathological data, treatments, outcomes and biological information from patients with recurrent / metastatic urothelial cancer. The study will cover 204 patients from Brazil, Mexico, Argentina, and

In September 2020, investigators from the LACOG Head and Neck Cancer Group published the results of the study:  “Health-related quality of life outcomes in head and neck cancer: results from a prospective, real-world data study with Brazilian patients treated with intensity modulated radiation therapy, conformal and conventional radiation techniques” in the well-known scientific periodical, International Journal of Radiation Oncology – Biology – Physics. The study involved 570 Brazilian patients with head or neck cancer and assessed the impact of three different types of radiotherapy: Intensity-Modulated Radiation Therapy (IMRT), conformational radiotherapy and conventional radiotherapy, on patients’ quality of life and overall survival. According to Dr. Marcos Santos, radio-oncologist at the CONFIAR-Goiânia Group and the principal investigator who carried out the study for the group, having a paper accepted for publication shows that Brazil is now playing an active part in producing the real world data that is relied upon by regulatory agencies around the world when making decisions on technology. “It also means that, if we invest in encouraging the use of IMRT to treat head and neck cancer, we can be confident that, depending on the amount, it will be of real help to patients.” The findings of the trial confirm that

The delay between diagnosis and the beginning of a disease treatment is a reality for many patients, oncological or not. Such delay has a significant impact on the quality of life and, in many cases, on overall survival of patients. Seeking to describe the journey of patients with ALK-positive non-small cell lung cancer, Dr. Eldsamira Mascarenhas, a clinical oncologist at Oncologia D'Or Salvador, along with LACOG, is coordinating the observational study: The journey of patients with ALK-positive advanced lung cancer in Brazil (LACOG 1918). “We wish to understand what patients with ALK-positive advanced lung cancer face from the moment they receive the diagnosis until the beginning of treatment. With this information, we will be able to act more effectively and therefore provide earlier diagnosis and therapy”, she explains. According to Dr. Mascarenhas, studies like this are important because there has been a significant increase in cancer incidence over the years. “Developing a clinical research will answer important questions we have about this population.” Dr. Mascarenhas believes that clinical research transforms society around the world. However, Brazil still does not play a prominent role in this scenario since we have had little participation in the development of studies. For that reason, the work