A study conducted by the Genitourinary Cancer Group has been published in an important American journal
In August, the journal Clinical Genitourinary Cancer published the study “First-line treatment of metastatic renal cell carcinoma in the immuno-oncology era: systematic review and network meta-analysis”, authored by a group of researchers from the LACOG Genitourinary Group. According to Dr. Fernando Sabino, a clinical oncologist at the Oncology and Hematology Center at Santa Lúcia Hospital and the Hospital of the University of Brasilia, the aim of the study was to compare and classify the different regimens available for first-line treatment of metastatic kidney cancer. This systematic review and meta-analysis has provided some important information on which treatments are most suitable for patients with this type of tumor, as there are, to date, no studies that compare the latest approaches, e.g. combining immunological agents of different classes or combining these agents with targeted molecular therapy. “The established outcomes we looked at were overall survival, progression-free survival and response rates. The study concluded that the treatments using immunotherapy are superior to the standard treatment with Sunitinib, and that there is no one immunotherapy based treatment that is significantly superior to any other.” In Dr. Sabino’s opinion, this study has had a significant impact on patients in Latin America, because five first-line line systemic therapeutic options
Non-small cell lung cancer is the subject of an important study for Brazil
The same way it happens in developed countries, non-small cell lung cancer (NSCLC) is generally diagnosed in its advanced stages and has poor survival rates in Brazil. Overall, approximately 70% of patients present with locally advanced or metastatic disease (stages III and IV, respectively) at diagnosis.1 In order to collect data on clinical characteristics, treatment patterns and outcomes of patients with stage III NSCLC in Brazil, Dr. Vladmir Cláudio Cordeiro de Lima started the observational study Retrospective epidemiological study of Locally Advanced Non-Small Cell Lung Cancer (LACOG 0118 – RELANCE). He has worked as the principal investigator of the study ever since. Dr. Cordeiro de Lima is a clinical oncologist at the Department of Clinical Oncology at the AC Camargo Cancer Center. He also works as a permanent advisor of the Postgraduate Course in Sciences focused on the Oncology area at the Antônio Prudente Foundation, and as an investigator at the Translational Immuno-oncology Laboratory (CIPE) at the Antônio Prudente Foundation. The study aims to describe the outcomes of 400 patients with locally advanced NSCLC (stage III). The study is supported by LACOG and, according to Dr. Cordeiro de Lima, this support is extremely important because cooperative groups help to bring together and
PALLAS study was presented at ESMO Virtual Congress 2020
The results of the PALLAS study, which evaluated the addition of Palbociclib to adjuvant endocrine therapy in breast cancer, were presented at the ESMOVirtual Congress 2020 on September 20, 2020.The PALLAS study was conducted by the Austrian Breast and Colorectal Cancer Study Group (ABCSG), Austria and the ALLIANCE Foundation Trials group - United States. LACOG participated in the study as part of a collaborative group working in Latin America along with Mexican research centers that made a significant contribution to the study.
13th Annual GEICAM Review of Advances in Breast Cancer
GEICAM started this initiative in 2008 with the purpose of presenting an in-depth review of the most relevant milestones presented at congresses and international publications annually. At this annual multidisciplinary meeting, attended by all professional involved with breast cancer, a comprehensive review of the advances made in research, diagnosis and treatment in connection with this disease has been carried out. The main goal of this event is to become a reference for everyone interested in finding out more about the advances made in terms of breast cancer in an independent, comprehensive and critical fashion. Sign up at: https://www.ragmageicam.org/ and participate!
The impact of sociodemographic factors and health insurance coverage in the diagnosis and clinicopathological characteristics of breast cancer in Brazil: AMAZONA III study (GBECAM 0115)
Members of LACOG Breast cancer group have recently published the article “The impact of sociodemographic factors and health insurance coverage in the diagnosis and clinicopathological characteristics of breast cancer in Brazil: AMAZONA III study (GBECAM 0115)” AMAZONA III/ GBECAM 0115 is a prospective cohort study that evaluated Brazilian patients with newly diagnosed breast cancer from 2016 to 2018. This manuscript depicts a wide and detailed scenario of sociodemographic characteristics of 2,950 breast cancer patients at diagnosis. The patients were from 23 sites in Brazil. The results of the study show that patients with public health coverage were diagnosed with symptomatic disease, at later stages and with more aggressive subtypes of breast cancer when compared to patients with private health coverage. This study brings to light important information that allows us to not only have a better understanding of tumor and patients’ characteristics but also, help to identify gaps within healthcare systems in Brazil. With such knowledge, it’s possible to develop strategies to improve screening and educational programs in the country, especially in the public setting.
GBCP and LACOG Head and Neck Group new members of the Head and Neck Cancer International Group
It is with great pleasure that we inform that GBCP and LACOG Head and Neck Group are now members of the Head and Neck Cancer International Group.
The CURA Project launched a crowdfunding campaign to support research against head and neck cancer
The CURA Project, of which we are supporters, launched a crowdfunding campaign to support research against head and neck cancer. Join us by supporting the campaign to fund 1,000 laboratory tests and contribute to scientific research. We invite you to join together in this great challenge of raising funds to clinical cancer research community. Access The CURA Project website and learn more! Access The Cura Project website
Assistance to cancer patients was dramatically compromised during the covid-19 pandemic, which will result in an increased risk of mortality by approximately 20%.
"A multidisciplinary group with 40 representatives from 35 collaborative groups and medical associations developed a consensus practice recommendations for the continuity of care for patients with head and neck cancer during the pandemic, stressing the importance of not interrupting their treatment, treating patients with established protocols, encouraging distance consultations, and adopting protective measures for patients and staff." - Dr. Prof. Luiz P. Kowalski, Vice-chair LACOG Head and Neck Group and A.C. Camargo Center Oncologist Read more on The Lancet website
Health-related quality of life outcomes in head and neck cancer: results from a prospective, real-world data study with Brazilian patients treated with intensity modulated radiation therapy, conformal and conventional radiation techniques
Marcos Santos, Luís Felipe Oliveira e Silva, Hugo F. Kohler, Otavio Curioni, Ricardo Vilela, Marcel Fang, Carmen Silvia Passos Lima, João Pedro Gomes, Aline Chaves, Bruno Resende, Karine Trindade, Mauricio Collares, Fernando Obs, Janaina Brollo, Ronaldo Cavalieri, Ediane Ferreira, Leandro Brust, Doralina Rabello, Christian Domenge, Luiz Paulo Kowalski - International Journal of Radiation Oncology. September 29, 2020
LBA12 – PALLAS: A randomized phase III trial of adjuvant palbociclib with endocrine therapy versus endocrine therapy alone for HR+/HER2- early breast cancer
E.L. Mayer, M.I. Gnant, A. DeMichele, M. Martin, H. Burstein, A. Prat, G. Rubovszky, K.D. Miller, G. Pfeiler, E.P. Winer, N. Zdenkowski, D. Anderson, Z. Nowecki, S. Loibl, H. Fohler, O. Metzger, D. Fumagalli, K. Puyana Theall, C. Fesl, A. Dueck - ESMO Virtual Congress 2020